Bis (4-aminophenyl)-sulfone ascorbate



Patented Aug. 29, 1950 2,520,438

UNITED STATES PATENT OFFICE BIS (l-AMINOPHENYL) -SULFON E ASCORBATE Peter P. T. Sah, San Francisco, Calif., assignor to Eli Lilly and Company, Indianapolis, Ind., a corporation of Indiana No Drawing. Application November 17, 1949, Serial No. 127,997

1 Claim. (Cl. 260239.65) z This invention relates to the di-l-ascorbate of utes and 300 cc. of chloroform are added. On bisw-amin-ophenyl)-su1fone, a new chemical standing, white, slightly water-soluble crystals compound possessing a high degree of bactericidal of the di-l-ascorbate of bis(4-aminophenyl) -su1- efiectiveness against microorganisms, inter alia ione separate. The crystals are filtered off and Mycobacterium tuberculosis and Mycobacterium purified by recrystallization from methanol. Zepme, and characterized by remarkably low M. P. 163165 C. Analysis: found, 4.84 percent toxicity. nitrogen; calculated, 4.97 percent.

The new chemical compound is prepared as I claim:

follows: As a new chemical compound, the di-l-ascor- 24.8 g. (0.1 mol) of pure bis(4-aminopheny1)- l0 bate of bisUl-aminophenyl)-su1fone.

sulfone are added to a solution of 35.2 g. (0.2 PETER P. T, SAI-I,

mol) of pure l-ascorbic acid in 150 cc. of boiling methanol. The mixture is refluxed for 10 min- No references cited. 

